个人简介

姓名：顾杰

性别：男

出生年月：1982年11月

职称：副研究员

E-mail: 1000004531@ujs.edu.cn

学术简历

学习经历：

2001/09-2005/06，扬州大学，生物科学与技术，学士学位

2005/09-2008/06，扬州大学，生物化学与分子生物学，硕士学位

2009/03-2011/02，香港浸会大学，生物学，硕士学位

2011/07-2014/06，香港浸会大学，生物学，博士学位

工作经历：

2014/07-2015/06，香港浸会大学，生物系，助理研究员

2015/06-2016/08，pg电子官网入口，生命科学研究院，助理研究员

2017/09-至今，pg电子官网入口，生命科学研究院，副研究员

研究兴趣

重金属的分子毒理与解毒机制

钙离子稳态失衡相关疾病

环境污染与临床疾病相关研究

科研项目

(1) 江苏省科学技术厅,青年基金，BK20210747，谷氨酰胺剂量调控乌鳢水泡病毒负责的机制研究，2021-07至2024-06，20万，在研，参加

(2) 苏州人人基因科技有限公司，1871330003，游离DNA（cell-free DNA, cfDNA）在肾移植免疫排斥中的应用技术开发，2017-12至2020-12，200万，已结题，参加

(3) 国家自然科学基金委员会,青年基金，31600952，钙离子敏感受体CaSR的激活可减轻镉对肾小管上皮细胞的毒性的分子机理的研究，2017-01至2019-12，20万，已结题，主持

(4) 香港General Research Fund项目，GRF 261610, The Identification of Stanniocalcin-1 Target Cells and the Characterization of the In-Situ Ca2+-Sensing and Transport Mechanisms in Gill Epithelial Cells of Japanese Eels, 2010-2013，HK$986,000，已结题，参与

近5年发表SCI论文

（1）Qin ZQ, Li KD, Chu HZ, Yuan XF, Shi HF, Gu J, Xie YM. Blocking stanniocalcin 2 reduces sunitinib resistance in clear cell renal cell carcinoma. Neoplasma. 2022 Jan; 69(1):145-154.

（2）Ning B, Guo C, Kong A, Li K Xie Y, Shi H, Gu J*. Calcium signaling mediates cell death and crosstalk with autophagy in kidney disease. Cells. 2021 Nov 10(11):3204.

（3）Kong A, Zhang Y, Ning B, Li K, Ren Z, Dai S, Chen D, Zhou Y, Gu J*, Shi H*. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca(2+) homeostasis. Chem Biol Interact. 2021 Sep 10:109649.

（4）Zhang Y, Li K, Kong A, Zhou Y, Chen D, Gu J, Shi H*. Dysregulation of autophagy acts as a pathogenic mechanism of non-alcoholic fatty liver disease (NAFLD) induced by common environmental pollutants. Ecotoxicol Environ Saf. 2021 Jul 1;217:112256.

（5）Sun X, Wang Y, Jiang T, Yuan X, Ren Z, Tuffour A, Liu H, Zhou Y, Gu J, Shi H*. Nephrotoxicity profile of cadmium revealed by proteomics in mouse kidney. Biological Trace Element Research. 2021 May;199(5):1929-1940.

（6）Tuffour A, Kosiba AA, Zhang Y, Peprah FA, Gu J, Shi H*. Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target. Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188528.

（7）Shi H, Sun X, Kong A, Ma H, Xie Y, Cheng D, Wong CKC, Zhou Y, Gu J*. Cadmium induces epithelial-mesenchymal transition and migration of renal cancer cells by increasing PGE2 through a cAMP/PKA-COX2 dependent mechanism. Ecotoxicology and Environmental Safety, 2021 Jan 1;207:111480.

（8）Yimin Xie, Jie Gu, Zhenqian Qin, Zhen Ren, Yanwei Wang, Haifeng Shi, Binghai Chen*. Long non coding RNA FAM66C is associated with clinical progression and promotes cell proliferation by inhibiting proteasome pathway in prostate cancer. Cell Biochemistry and Function, 2020. Dec;38(8):1006-1016

（9）Liu H, Wang Y, Ren Z, Ji X, Addai PF, Zhang X, Dai S, Zhou Y, Gu J*, Shi H*. Dietary cadmium exposure causes elevation of blood ApoE with triglyceride level in mice. Biometals. 2020 Oct;33(4-5):241-254.

（10）Keng Po Lai, Xiao Lin, Nathan Tam, Jeff Cheuk Hin Ho, Marty Kwok-Shing Wong, Jie Gu, Ting Fung Chan, William Ka Fai Tse. Osmotic stress induces gut microbiota community shift in fish. Environ Microbiol. 2020 Sep;22(9):3784-3802.

（11）Xie Y, Yuan X, Zhou W, Kosiba AA, Shi H, Gu J, Qin Z. The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression: Review. Life Sci. 2020 Aug 1;254:117252.

（12）Gu J, Ren Z, Zhao J, Peprah FA, Xie Y, Cheng D, Wang Y, Liu H, Chu Wong CK, Zhou Y, Shi H*. Calcimimetic compound NPS R-467 protects against chronic cadmium-induced mouse kidney injury by restoring autophagy process. Ecotoxicol Environ Saf. 2020 Feb, 189:110052.

（13）Kosiba AA, Wang Y, Chen D, Wong CKC, Gu J, Shi H*. The roles of calcium-sensing receptor (CaSR) in heavy metals-induced nephrotoxicity. Life Sci. 2020 Feb 1;242:117183.

（14）Gu J, Wang Y, Liu Y, Shi M, Yin L, Hou Y, Zhou Y, Chu Wong CK, Chen D, Guo Z, Shi H. Inhibition of autophagy alleviates cadmium-induced mouse spleen and human B cells apoptosis. Toxicol Sci. 2019 Jul 1;170(1):109-122.

（15）Wang Y, Ji X, Dai S, Liu H, Yan D, Zhou Y, Gu J*, Shi H*. Cadmium induced redistribution of cholesterol by upregulating ABCA1 and downregulating OSBP. J Inorg Biochem. 2018 Dec;189:199-207.

（16）Cao Q, Liang F, Wang D, Zhang X, Lorin-Nebel C, Gu J, Yin S. Dynamic expression of vasotocin and isotocin receptor genes in the marbled eel (Anguilla marmorata) following osmotic challenges. Gene. 2018 Nov 30;677:49-56.

（17）Chen B, Jiao Z, Yin X, Qian Z, Gu J*, Sun H. Novel insights into biomarkers associated with renal cell carcinoma. Oncol Lett. 2018 Jul;16(1):83-90.

（18）Cao Q, Gu J, Wang D, Liang F, Zhang H, Li X, Yin S*. Physiological mechanism of osmoregulatory adaptation in anguillid eels. Fish Physiol Biochem. 2018 Apr;44(2):423-433

（19）Gu J^#, Dai S^#, Liu H, Cao Q, Yin S, Lai KP, Tse WKF, Wong CKC, Shi H*. Identification of immune-related genes in gill cells of Japanese eels (Anguilla japonica) in adaptation to water salinity changes. Fish Shellfish Immunol. 2018 Feb;73:288-296.

（20）Gu J^#, Dai S^#, Liu Y, Liu H, Zhang Y, Ji X, Yu F, Zhou Y, Chen L, Tse WKF, Wong CKC, Chen B, Shi H*. Activation of Ca2+-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells. Sci Rep. 2018 Jan 18;8(1):1092.

（更新于2022年5月6日）