【个人简介】

姓名          吕鹏

性别          男

出生日期   1983.12

职称          副研究员

E-mail       pengluATujs.edu.cn 使用时用@替代AT

【学术简介】

学习经历：

2002-2006年   pg电子官网入口 生物技术

2006-2009年   pg电子官网入口 生物化学与分子生物学

2011-2014年   pg电子官网入口 食品营养与安全

工作经历：

2009-2010年  中科院上海巴斯德研究所

2010-2011年  北京西美杰科技有限公司

2014-至今      pg电子官网入口生命科学研究院

【主讲课程】

硕士研究生：生物仪器分析与实验技术，基因工程原理

【研究领域】

昆虫病毒与宿主相互作用机制；

基因工程抗体筛选及应用；

SHERLOCK核酸检测及新型核酸检测技术开发。

【科研项目】

1. 横向课题（上海触研生物科技有限公司），肺癌筛查检测产品研发，主持；

2. 横向课题（江苏美正生物），农残快速检测生物性原料筛选和制备，主持；

3. 横向课题（南京师范大学），FEN1人源化抗体的筛选，主持；

4. 江苏省重点研发计划（BE2017651），应用基因工程抗体的新型尿液检测雌酮孕酮（荧光定量免疫层析法）POCT产品的研发，主持，在研；

5. 国家自然基金青年基金（31602008），家蚕蛋白MyosinII在BmNPV诱导宿主自噬以及病毒复制增殖中的作用机制研究，主持，在研；

6. 镇江市重点研发计划（SH2016013），应用于新型尿液检测雌酮孕酮产品的基因工程抗体的筛选，主持，结题；

7. 江苏省自然基金青年基金（BK20150495），家蚕羧酸酯酶Bmae45及其抗BmNPV机制研究，主持，结题；

8. 中国博士后科学基金（2015M571701），家蚕自噬在杆状病毒BmNPV感染增殖中的作用机制研究，主持，在研。

【主要论著】

2022年

1. Funmilayo O. Fapohunda, Seng Qiao, Ye Pan, Huiying Wang, Yuan Liu, Peng Lü*, CRISPR Cas system: a strategic approach in detection of nucleic acids, Microbiological Research, 2022, In press.

2021年

2. Peng Lü, Songlin Qiu, Ye Pan, Shenyan Shi, Qian Yu, Feng Yu, Lianjun Miao, Huiying Wang, Keping Chen, Discovery of an Heparin-binding epidermal growth factor domain antibody from a phage library and analysis of its inhibitory effects in SKOV3 cells, Cancer Biotherapy and Radiopharmaceuticals, 2021, online ahead of print.

3. Min Tang, Suqun He, Xun Gong, Peng Lü, Reha H Taha, Keping Chen, High-Quality de novo chromosome-level genome assembly of a single Bombyx mori with BmNPV resistance by a combination of PacBio long-reading sequencing, Illumina Short-read sequencing, and Hi-C sequencing, Frontiers in Genetics, 2021, 12.

4. Qian Yu, Pengfei Chang, Xiaoxuan Liu, Peng Lü, Qi Tang, Zhongjian Guo, Jianming Qiu, Keping Chen, Qin Yao, Bombyx mori pupae efficiently produce recombinant AAV2/HBoV1 vectors with a Bombyx mori nuclear polyhedrosis virus expression system, Viruses, 2021, 13(4), 704.

5. Rui Liu, Suleiman A Haruna, Shujat Ali, Jing Xu, Yunlian Zhang, Peng Lü, Huanhuan Li, Quansheng Chen, A sensitive and accurate fluorescent genosensor for Staphylococcus aureus detection, Sensors and Actuators B: Chemical, 131311.

6. Yuan Liu, Shu Liu, Chongxin Xu, Manman Lin, Yihang Li, Cheng Shen, Ying Liang, Xing Sun, Donglan Wang, Peng Lü, Xianjin Liu, Epitopes prediction for microcystin-LR by molecular docking, Ecotoxicology and Environmental Safety, 2021, 227, 112925.

2020年

7. Songlin Qiu, Ye Pan, Zhigang Guo*, Peng Lü*, Genetic mechanism of leukemia relapse following CD19 chimeric antigen receptor T-cell therapy, Cancer Biotherapy and Radiopharmaceuticals, 2020, online ahead of print.

8. Peng Lü*#, Songlin Qiu#, Ye Pan, Feng Yu, Keping Chen, Pre-clinical CAR-T progress in digestive system cancers, Cancer Biotherapy and Radiopharmaceuticals, 2020, 36(4), 307-315.

9. Zhichao Nie#, Peng Lü#, Min Tu, Zhanzhuang Zeng, Rusong Zhang, Yishuai Tu, Zhenni Liu, Yin Li, Hong Zhang*, a simple and rapid method for fish sex identification based on recominase-aided amplification: an example of Cynoglossus semilaevis, Scientific Reports, 2020, 11(1), 1-11.  

10. Xue Han#, Peng Lv#, Luguang Wang, Fei Long, Xiaolin Ma, Chang Liu, Yujie Feng, Mingfeng Yang and Xiang Xiao*, Impact of nano-TiO2 on horizontal transfer of resistance genes mediated by filamentous phage transduction, Environmental Science Nano, 2020,4.

9. Feifei Zhu, Dong Li, Dandan Song, Shuhao Huo, Shangshang Ma, Peng Lü, Xiaoyong Liu, Qin Yao, Keping Chen, Glycoproteome in silkworm Bombyx mori and alteration by BmCPV infection, Journal of Proteomics, 222, 103802.

2019年

11. Peng Lü, Yaling He, Feng Lin, Ye Pan, Qian Yu, Zhongjian Guo, Chengjun Li, Huiying Wang, Qin Yao*, Yan Fu* and Keping Chen*, Rapid detection of Bombyx mori bidensovirus by loop-mediated isothermal amplification based lateral flow dipstick assay for field applications, Journal of Invertebrate Pathology, 2019, 163:75-81.

12. Rui Li, Pengfei Chang, Peng Lü, Zhaoyang Hu, Keping Chen Qin Yao, Qian Yu, Characterization of the RNA transcription profile of Bombyx mori Bidensovirus, Viruses, 2019, 11(4), 325.

2018年

13. Peng Lü, Ye Pan, Yanhua Yang, Feifei Zhu, Chengjun Li, Qin Yao and Keping Chen*, Discovery of anti-viral molecules and their vital functions in Bombyx mori, Journal of Invertebrate Pathology, 2018, 154: 12-18.

2014-2017年

14. Peng Lü, Yali Xing, Zhaoyang Hu, Yanhua Yang, Ye Pan, Kangmin Chen, Feifei Zhu, Yajing Zhou, Keping Chen and Qin Yao*, A characterization of structural proteins expressed by Bombyx mori bidensovirus, Journal of Invertebrate Pathology, 2017, 144: 18-23。

15. Ye Pan, Peng Lü, Qinyun Wang, Feifei Zhu, Chengjun Li, Yuanqing He and Keping   Chen*, Comparative transcriptomic analysis of Bombyx mori fat body tissue following dietary restriction, Archives of Insect Biochemistry and Physiology, 2017, 95(1): e21388.

16. Zhichao Nie, Peng Lü*, Qiang Wang, Xu Meng, Shuang Lu, Xin Dong and Keping Chen*, Reference gene selection for quantitative real-time polymerase chain reaction analysis in Bombyx mori nucleopolyhedrovirs-infected silkworms, Invertebrate Survival Journal, 2017, 14: 94-102.

17. Xin Dong, Peng Lü, Wu Cao, Chi Zhang, Feifei Zhu, Xu Meng, Zhichao Nie, Shuang Lu and Keping Chen*, Study of the toxicity of Bacillus cereus on silkworm (Bombyx mori) and the relevant proteome, Invertebrate Survival Journal, 2017, 14: 129-139

18. Caixia Lian, Lingling Ruan, Dongsheng Shang, Yanfang Wu, Yongjin Lu, Peng Lü, Yuhua Yang, Yajun Wei, Xiaojing Dong, Dewan Ren, Keping Chen, Hanqing Liu and Zhigang Tu*, Heparin-binding epidermal growth factor-like growth factor as potent target for breast cancer therapy, Cancer Biotherapy & Radiopharmaceuticals, 2016, 31(3): 85-90.

19. Zhicai Zhang*, Lili Xia, Feng Wang, Peng Lv, Maxiaoqi Zhu, Jinhua Li and Keping Chen, Lignin degradation in corn stalk by combined method of H2O2 hydrolysis and Aspergillus oryzae CGMCC5992 liguid-state fermentation, Biotechnology for Biofuels, 2015, 8(1): online.

20. Xiaoli Pan, Peng Lü, Miaomiao Zhang, Zhaoyang Hu, Guohui Li, Shangshang Ma, Fan Feng, Keping Chen, Qin Yao*, Expression Analysis of Bombyx mori Bidensovirus Structural Proteins and Assembly of Virus-like Particles in Insect Cells, Current Microbiology, 2014, 69(4): 567-573

2013年

21. Peng Lü, Hengchuan Xia, Lu Gao, Ye Pan, Yong Wang, Xin Cheng, Honggang Lü, Feng Lin, Liang Chen, Qin Yao, Xiaoyong Liu, Qi Tang, Keping Chen*, V-ATPase Is Involved in Silkworm Defense Response against Bombyx mori Nucleopolyhedroviurs, PLoS One, 2013, 8(6): e64962.

2013年以前

22. Peng Lü, Keping Chen*, Qin Yao, Lu Gao, Ye Pan, Yuanqing He, Guoping Huang, Lin Wang, Expression and Localization of Bombyx mori V-ATPase 16 kDa Subunit c, Zeitschrift für Naturforschung C, 2010, 65(1-2): 119-126.

23. Ye Pan, Peng Lü, Yong Wang, Lijing Yin, Hexiang Ma, Guohong Ma, Keping Chen, Yuanqing He*, In silico identification of novel chitinase-like proteins in the silkworm, Bombyx mori, genome, Journal of Insect Science, 2012, 12.

【科研成果、教学成果及奖励】

2016年江苏省科技进步三等奖（4/7）

【授权专利】

4项，转化2项